I feel like I'm doing the tour of first world problems here, because here's mine:
I'm not sure I'll ever get used to PC controls.
Now, this is just the second game (Tomb Raider being the first), that I've played on a PC, so maybe it's that.
Or maybe it's just the fact that 3rd person games will never be as comfortable on a keyboard and mouse as they are with just a controller.
I don't know what was up with JC2, but I played through the first couple of missions (the 2 before they put you on the island to free roam) and I just couldn't do anything right.
I just felt like a klutz trying to do anything with the grappling hook. It took me far too long to scale one of the big buildings and I just felt like an idiot.
I hear that, though not as easy as an xbox controller, that it is possible to hook up a PS3 controller to your computer. I'll probably be looking into that.
Of course, then I'll have the first world problem of needing to sit too far away from my 11.6" screen in order to use the controller.
At heart, I'm really just more cut out to be an unwashed console peasant.